Conventional tablet formulation has acquired the 50 to 60 % market stake. But with this tablet having acceptance problem in the patients suffering from dysphagia, Parkinson’s disease, mycosystis or vomiting, geriatric and pediatric patient because unwilling to take solid preparations due to fear of choking. From the patient point of view Fast dissolving film offers ease of administration and improved compliance. Research and development in the oral drug delivery system has led to transition of dosage forms from simple conventional tablets/capsules to modified release tablets/capsules followed by oral disintegrating tablet (ODT). Further development leads to formulation of wafer of which oral fast dissolving film (FDF) are most preferred. Since, review forms basis for research, current article exhaustively covers formulation aspects of FDF including natural and synthetic polymers as film formers. It also focuses on formulation methods like Solvent casting, hot melt extrusion, roller compaction etc. and technologies like FOAM BURST, SOLULEAVES, WAFER TAB etc. that have made products like Zofran, Listerine, Gas- X etc. popular in public domain. An important aspect of FDF is making new business opportunities available for the same drug. In the post GATT era, where patents of many high selling drugs are expiring, a lot of new opportunities can be created by incorporating the drug in a novel dosage forms.
Loading....